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Weizheng Xu Selected Research

GPI 15427

3/2010Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427.
3/2008PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
8/2006Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma.
12/2005Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock.
2/2005Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.
11/2003Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma.

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Weizheng Xu Research Topics

Disease

6Neoplasms (Cancer)
01/2011 - 11/2003
3Inflammation (Inflammations)
08/2006 - 06/2004
3Shock
12/2005 - 06/2004
2Diabetes Complications
10/2011 - 03/2008
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2011 - 12/2009
2Hyperalgesia
03/2008 - 05/2006
2Lymphoma (Lymphomas)
02/2005 - 11/2003
2Melanoma (Melanoma, Malignant)
02/2005 - 11/2003
1Hyperglycemia
10/2011
1Peripheral Nervous System Diseases (PNS Diseases)
10/2011
1Hypertrophy
10/2011
1Atrophy
06/2010
1Diabetic Neuropathies (Diabetic Neuropathy)
06/2010
1Kidney Diseases (Kidney Disease)
04/2010
1Diabetic Nephropathies (Diabetic Nephropathy)
04/2010
1Head and Neck Neoplasms (Head and Neck Cancer)
03/2010
1Squamous Cell Carcinoma of Head and Neck
03/2010
1Cataract (Cataracts)
04/2009
1Edema (Dropsy)
10/2006
1Spinal Cord Injuries (Spinal Cord Injury)
10/2006
1Wounds and Injuries (Trauma)
10/2006
1Myelitis
10/2006
1Colorectal Neoplasms (Colorectal Cancer)
08/2006
1Carcinoma (Carcinomatosis)
08/2006
1Colonic Neoplasms (Colon Cancer)
08/2006
1Diarrhea
08/2006
1Neuralgia (Stump Neuralgia)
05/2006
1Ischemia
12/2005
1Colitis
12/2005
1Brain Neoplasms (Brain Tumor)
02/2005
1Experimental Melanoma
02/2005
1Body Weight (Weight, Body)
06/2004
1Septic Shock (Toxic Shock Syndrome)
06/2004
1Neoplasm Metastasis (Metastasis)
11/2003
1Glioma (Gliomas)
11/2003
1Glioblastoma (Glioblastoma Multiforme)
11/2003

Drug/Important Bio-Agent (IBA)

9Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
10/2011 - 11/2003
8Poly(ADP-ribose) Polymerase InhibitorsIBA
10/2011 - 08/2006
6GPI 15427IBA
03/2010 - 11/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010 - 04/2005
3Pharmaceutical PreparationsIBA
06/2010 - 11/2003
3Streptozocin (Streptozotocin)FDA Link
04/2010 - 03/2008
3Temozolomide (Temodar)FDA LinkGeneric
08/2006 - 11/2003
3Poly (ADP-Ribose) Polymerase-1IBA
12/2005 - 11/2003
2Poly Adenosine Diphosphate RiboseIBA
03/2010 - 06/2004
2poly ADP-ribose glycohydrolaseIBA
10/2006 - 06/2004
1p38 Mitogen-Activated Protein KinasesIBA
10/2011
1VitaminsIBA
01/2011
1FlavonoidsIBA
01/2011
13-nitrotyrosineIBA
06/2010
1NitritesIBA
06/2010
1Biomarkers (Surrogate Marker)IBA
06/2010
1NitratesIBA
06/2010
1Retinaldehyde (Retinal)IBA
04/2009
1SaltsIBA
03/2008
1Drinking WaterIBA
03/2008
1Mesylates (Mesylate)IBA
03/2008
1Formaldehyde (Formol)FDA Link
03/2008
1CytokinesIBA
10/2006
1Inflammation MediatorsIBA
10/2006
1Interleukin-1beta (Interleukin 1 beta)IBA
10/2006
1Irinotecan (Camptosar)FDA LinkGeneric
08/2006
1Adenosine Diphosphate Ribose (ADP-Ribose)IBA
08/2006
1Topoisomerase I InhibitorsIBA
08/2006
13-(1-carboxy-4-mercaptobutoxy)benzoic acidIBA
05/2006
1Benzoic Acid (Potassium Benzoate)FDA Link
05/2006
1DNA (Deoxyribonucleic Acid)IBA
12/2005
1Sulfonic AcidsIBA
12/2005
1EnzymesIBA
12/2005
1DinitrobenzenesIBA
12/2005
12- (4- methylpiperazin- 1- yl)- 5H- benzo(c)(1,5)naphthyridin- 6- oneIBA
12/2005
12,4-dinitrofluorobenzene sulfonic acidIBA
12/2005
1SuspensionsIBA
06/2004
1ZymosanIBA
06/2004
1A-Form DNA (A-DNA)IBA
11/2003

Therapy/Procedure

2Oral Administration
08/2006 - 05/2006
1Therapeutics
04/2010
1Radiotherapy
03/2010
1Laminectomy
10/2006
1Drug Therapy (Chemotherapy)
08/2006
1Intravenous Injections
02/2005